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Does the Thrustmaster TCA Quadrant Boeing Edition work with MSFS 2020 default aircraft?

Compatible Yes. The linked source says it works.

On Microsoft's official recommended-peripherals list (PC). List last updated Mar 6, 2024, so it does not confirm MSFS 2024.

Source: Microsoft recommended peripherals list (updated Mar 6, 2024)

Checked 2026-10-16.

Full Thrustmaster TCA Quadrant Boeing Edition page

Buy at Thrustmaster US eshop: $169.99
Price checked 2026-10-23. In stock when checked. Store links are direct, with no affiliate code.
Lowest price we saw in the 30 days to 2026-11-10: $169.99 at Thrustmaster USA eshop on 2026-10-23 (2 check dates).

Other sims the maker page confirms